• Introduction: It is a chronic inflammatory disorder affecting many joints, including those in the hands and feet. RA can also affect other tissues throughout the body and cause problems in organs such as the lungs, heart, and eyes. In RA the body's immune system attacks its own tissue, including joints and In severe cases, it attacks internal organs also. • Defination : Rheumatoid arthritis (RA) is a multisystem inflammatory disease primarily affecting the synovium and adjacent tissues. • Cause/Etiology : - Unknown - Immunogenic factors - hormonal factors: Incidence of it in women is greater before menopause and remission of it during pregnancy is well known. - OCP - low socio - economic status - viral and bacterial infection triggers the RA. • Risk factors: - Age: 40-60 year - sex: most common in women than me...